Camera vision positioning laser welding machine, using high resolution industrial camera, real-time shooting of the dynamic image of the workpiece. The coordinate change of dynamic workpiece is confirmed by comparing the position of working workpiece and template workpiece. The visual positioning accuracy can be set freely according to the application requirements, up to 10 microns. The camera calibration function realizes the transformation between the visual coordinates and the physical coordinates and can track the target of any shape. The tracking range can be set, and a variety of calibration methods such as cross line, positioning box and positioning circle can be set and switched with one key. Through certain calculation, the offset coordinates are automatically moved to the correct position, so that the marked graph can be welded in the correct position.